Selected publications
Cecotto L, van Kessel K, Wolfert MA, Vogely C, van der Wal B, Weinans H, van Strijp J, Amin Yavari S. “Antibacterial and anti-inflammatory properties of host defense peptides against Staphylococcus aureus.” iScience. 2022 Sep 24;25(10):105211. doi: 10.1016/j.isci.2022.105211. (Pubmed: 36248729)
Boero E, Cruz AR, Pansegrau W, Giovani C, Rooijakkers SHM, van Kessel KPM, van Strijp JAG, Bagnoli F, Manetti AGO. “Natural Human Immunity Against Staphylococcal Protein A Relies on Effector Functions Triggered by IgG3.” Front Immunology. 2022 Mar 11;13:834711. doi: 10.3389/fimmu.2022.834711. (Pubmed: 35359919)
Cruz AR, van Strijp JAG, Bagnoli F, Manetti AGO. “Virulence Gene Expression of Staphylococcus aureus in Human Skin.” Front Microbiology. 2021 Jun 11;12:692023. doi: 10.3389/fmicb.2021.692023. eCollection 2021. (Pubmed: 34177874)
Boero E, Brinkman I, Juliet T, van Yperen E, van Strijp JAG, Rooijakkers SHM, van Kessel KPM. “Use of Flow Cytometry to Evaluate Phagocytosis of Staphylococcus aureus by Human Neutrophils.” Front Immunology. 2021 Feb 19;12:635825. doi: 10.3389/fimmu.2021.635825. eCollection 2021. (Pubmed: 33679791)
Tromp AT, van Strijp JAG. “Studying Staphylococcal Leukocidins: A Challenging Endeavor.” Front Microbiology. 2020 Apr 15;11:611. doi: 10.3389/fmicb.2020.00611 (Pubmed: 32351474)
Tromp AT, Zhao Y, Jongerius I, Heezius ECJM, Abrial P, Ruyken M, van Strijp JAG, de Haas CJC, Spaan AN, van Kessel KPM, Henry T, Haas PA. “Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein.” Dis Model Mech. 2020 Sep 28;13(9):dmm045534. doi: 10.1242/dmm.045534 (Pubmed: 32471891)
Tromp AT, Van Gent M, Jansen JP, Scheepmaker LM, Velthuizen A, De Haas CJC, Van Kessel KPM, Bardoel BW, Boettcher M, McManus MT, Van Strijp JAG, Lebbink RJ, Haas PA, Spaan AN. “Host-Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity.” Toxins (Basel). 2020 Feb 6;12(2):106. doi: 10.3390/toxins12020106. (Pubmed: 32041354)
Zhao Y, van Woudenbergh E, Zhu J, Heck AJR, van Kessel KPM, de Haas CJC, Aerts PC, van Strijp JAG, McCarthy AJ. “The Orphan Immune Receptor LILRB3 Modulates Fc Receptor-Mediated Functions of Neutrophils.” J Immunol. 2020 Feb 15;204(4):954-966. doi: 10.4049/jimmunol.1900852. (Pubmed: 31915259)
de Jong NWM, van Kessel KPM, van Strijp JAG. “Immune Evasion by Staphylococcus aureus.” Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0061-2019 (Pubmed: 30927347)
Haapasalo K, Wollman AJM, de Haas CJC, van Kessel KPM, van Strijp JAG, Leake MC. “Staphylococcus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand sequestration.” FASEB J. 2019 Mar;33(3):3807-3824 (Pubmed: 30509126)
Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Jan Lebbink R, Haas PA, Henry T, Spaan AN. “Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin“. Nat Microbiol. 2018 June; 3:708–717 (Pubmed: 29736038)
de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, Geisbrecht BV, Haas PA. “Immune evasion by a staphylococcal inhibitor of myeloperoxidase”. Proc Natl Acad Sci USA. 2017 Aug 14. pii: 201707032 (Pubmed: 28808028)
Spaan AN, van Strijp JAG, Torres VJ. “Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors”. Nat Rev Microbiol. 2017 Jul;15(7):435-447 (Pubmed: 28420883)
Koop G, Vrieling M, Storisteanu DM, Lok LS, Monie T, van Wigcheren G, Raisen C, Ba X, Gleadall N, Hadjirin N, Timmerman AJ, Wagenaar JA, Klunder HM, Fitzgerald JR, Zadoks R, Paterson GK, Torres C, Waller AS, Loeffler A, Loncaric I, Hoet AE, Bergström K, De Martino L, Pomba C, de Lencastre H, Ben Slama K, Gharsa H, Richardson EJ, Chilvers ER, de Haas C, van Kessel K, van Strijp JA, Harrison EM, Holmes MA. “Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus”. Sci Rep. 2017 Jan 20;7:40660 (Pubmed: 28106142)
Koymans KJ, Bisschop A, Vughs MM, van Kessel KP, de Haas CJ, van Strijp JA. “Staphylococcal Superantigen-Like Protein 1 and 5 (SSL1 & SSL5) Limit Neutrophil Chemotaxis and Migration through MMP-Inhibition”. Int J Mol Sci. 2016 Jul 5;17(7). (Pubmed: 27399672)
Spaan AN, Reyes-Robles T, Badiou C, Cochet S, Boguslawski KM, Yoong P, Day CJ, de Haas CJ, van Kessel KP, Vandenesch F, Jennings MP, Le Van Kim C, Colin Y, van Strijp JA, Henry T, Torres VJ. “Staphylococcus aureus Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes”. Cell Host Microbe. 2015 Sep 9;18(3):363-70 (Pubmed: 26320997)
Koymans KJ, Feitsma LJ, Brondijk TH, Aerts PC, Lukkien E, Lössl P, van Kessel KP, de Haas CJ, van Strijp JA, Huizinga EG. “Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3)”. Proc Natl Acad Sci USA. 2015 Sep 1;112(35):11018-23 (Pubmed: 26283364)
Vrieling M, Koymans KJ, Heesterbeek DA, Aerts PC, Rutten VP, de Haas CJ, van Kessel KP, Koets AP, Nijland R, van Strijp JA. “Bovine Staphylococcus aureus Secretes the Leukocidin LukMF’ To Kill Migrating Neutrophils through CCR1”. MBio. 2015 Jun 4;6(3):e00335 (Pubmed: 26045537)
Spaan AN, Vrieling M, Wallet P, Badiou C, Reyes-Robles T, Ohneck EA, Benito Y, de Haas CJ, Day CJ, Jennings MP, Lina G, Vandenesch F, van Kessel KP, Torres VJ, van Strijp JA, Henry T. “The staphylococcal toxins γ-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors”. Nat Commun. 2014 Nov 11;5:5438. (Pubmed: 25384670)
Spaan AN, Surewaard BG, Nijland R, van Strijp JA. “Neutrophils versus Staphylococcus aureus: a biological tug of war”. Annu Rev Microbiol. 2013;67:629-50. (Pubmed: 23834243)
Spaan AN, Henry T, van Rooijen WJ, Perret M, Badiou C, Aerts PC, Kemmink J, de Haas CJ, van Kessel KP, Vandenesch F, Lina G, van Strijp JA. “The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors”. Cell Host Microbe. 2013 May 15;13(5):584-94. (Pubmed: 23684309)
Surewaard BG, Nijland R, Spaan AN, Kruijtzer JA, de Haas CJ, van Strijp JA. “Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles”. PLoS Pathog. 2012;8(3):e1002606. (Pubmed: 22457627)
Bardoel BW, van der Ent S, Pel MJ, Tommassen J, Pieterse CM, van Kessel KP, van Strijp JA. “Pseudomonas evades immune recognition of flagellin in both mammals and plants”. PLoS Pathog. 2011 Aug;7(8):e1002206.(Pubmed: 21901099)
Serruto D, Rappuoli R, Scarselli M, Gros P, van Strijp JA. “Molecular mechanisms of complement evasion: learning from staphylococci and meningococci”. Nat Rev Microbiol. 2010 Jun;8(6):393-9. (Pubmed: 20467445)
Bestebroer J, De Haas CJ, Van Strijp JA. “How microorganisms avoid phagocyte attraction”. FEMS Microbiol Rev. 2010 May;34(3):395-414. (Pubmed: 20059549)
Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P. “Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor”. Nat Immunol. 2009 Jul;10(7):721-7. (Pubmed: 19503103)
Bestebroer J, van Kessel KP, Azouagh H, Walenkamp AM, Boer IG, Romijn RA, van Strijp JA, de Haas CJ. “Staphylococcal SSL5 inhibits leukocyte activation by chemokines and anaphylatoxins”. Blood. 2009 Jan 8;113(2):328-37. (Pubmed: 18941109)
Rooijakkers SH, Ruyken M, Roos A, Daha MR, Presanis JS, Sim RB, van Wamel WJ, van Kessel KP, van Strijp JA. “Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases”. Nat Immunol. 2005 Sep;6(9):920-7. (Pubmed: 16086019)
de Haas CJ, Veldkamp KE, Peschel A, Weerkamp F, Van Wamel WJ, Heezius EC, Poppelier MJ, Van Kessel KP, van Strijp JA. “Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent”. J Exp Med. 2004 Mar 1;199(5):687-95. (Pubmed: 14993252)
Peschel A, Jack RW, Otto M, Collins LV, Staubitz P, Nicholson G, Kalbacher H, Nieuwenhuizen WF, Jung G, Tarkowski A, van Kessel KP, van Strijp JA. “Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine”. J Exp Med. 2001 May 7;193(9):1067-76. (Pubmed: 11342591)